Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1
Identifieur interne : 005F69 ( Main/Exploration ); précédent : 005F68; suivant : 005F70Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1
Auteurs : Shigetomo Fukuhara [Japon] ; Keisuke Sako [Japon] ; Kazuomi Noda [Japon] ; Kaori Nagao [Japon] ; Koichi Miura [Japon] ; Naoki Mochizuki [Japon]Source :
- Experimental & Molecular Medicine [ 1226-3613 ] ; 2009.
Abstract
Angiopoietin-1 (Ang1) binds to and activates Tie2 receptor tyrosine kinase. Ang1-Tie2 signal has been proposed to exhibit two opposite roles in the controlling blood vessels. One is vascular stabilization and the other is vascular angiogenesis. There has been no answer to the question as to how Tie2 induces two opposite responses to the same ligand. Our group and Dr. Alitalo's group have demonstrated that trans-associated Tie2 at cell-cell contacts and extracellular matrix (ECM)-anchored Tie2 play distinct roles in the endothelial cells. The complex formation depends on the presence or absence of cell-cell adhesion. Here, we review how Ang1-Tie2 signal regulates vascular maintenance and angiogenesis. We further point to the unanswered questions that must be clarified to extend our knowledge of vascular biology and to progress basic knowledge to the treatment of the diseases in which Ang1-Tie2-mediated signal is central.
Url:
DOI: 10.3858/emm.2009.41.3.016
PubMed: 19293632
PubMed Central: 2679245
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 004C51
- to stream Pmc, to step Curation: 004C50
- to stream Pmc, to step Checkpoint: 003563
- to stream Ncbi, to step Merge: 003292
- to stream Ncbi, to step Curation: 003292
- to stream Ncbi, to step Checkpoint: 003292
- to stream Main, to step Merge: 006040
- to stream Main, to step Curation: 005F69
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1</title><author><name sortKey="Fukuhara, Shigetomo" sort="Fukuhara, Shigetomo" uniqKey="Fukuhara S" first="Shigetomo" last="Fukuhara">Shigetomo Fukuhara</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author><author><name sortKey="Sako, Keisuke" sort="Sako, Keisuke" uniqKey="Sako K" first="Keisuke" last="Sako">Keisuke Sako</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author><author><name sortKey="Noda, Kazuomi" sort="Noda, Kazuomi" uniqKey="Noda K" first="Kazuomi" last="Noda">Kazuomi Noda</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author><author><name sortKey="Nagao, Kaori" sort="Nagao, Kaori" uniqKey="Nagao K" first="Kaori" last="Nagao">Kaori Nagao</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author><author><name sortKey="Miura, Koichi" sort="Miura, Koichi" uniqKey="Miura K" first="Koichi" last="Miura">Koichi Miura</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author><author><name sortKey="Mochizuki, Naoki" sort="Mochizuki, Naoki" uniqKey="Mochizuki N" first="Naoki" last="Mochizuki">Naoki Mochizuki</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19293632</idno><idno type="pmc">2679245</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679245</idno><idno type="RBID">PMC:2679245</idno><idno type="doi">10.3858/emm.2009.41.3.016</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">004C51</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004C51</idno><idno type="wicri:Area/Pmc/Curation">004C50</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004C50</idno><idno type="wicri:Area/Pmc/Checkpoint">003563</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003563</idno><idno type="wicri:Area/Ncbi/Merge">003292</idno><idno type="wicri:Area/Ncbi/Curation">003292</idno><idno type="wicri:Area/Ncbi/Checkpoint">003292</idno><idno type="wicri:doubleKey">1226-3613:2009:Fukuhara S:tie:is:tied</idno><idno type="wicri:Area/Main/Merge">006040</idno><idno type="wicri:Area/Main/Curation">005F69</idno><idno type="wicri:Area/Main/Exploration">005F69</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1</title><author><name sortKey="Fukuhara, Shigetomo" sort="Fukuhara, Shigetomo" uniqKey="Fukuhara S" first="Shigetomo" last="Fukuhara">Shigetomo Fukuhara</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author><author><name sortKey="Sako, Keisuke" sort="Sako, Keisuke" uniqKey="Sako K" first="Keisuke" last="Sako">Keisuke Sako</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author><author><name sortKey="Noda, Kazuomi" sort="Noda, Kazuomi" uniqKey="Noda K" first="Kazuomi" last="Noda">Kazuomi Noda</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author><author><name sortKey="Nagao, Kaori" sort="Nagao, Kaori" uniqKey="Nagao K" first="Kaori" last="Nagao">Kaori Nagao</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author><author><name sortKey="Miura, Koichi" sort="Miura, Koichi" uniqKey="Miura K" first="Koichi" last="Miura">Koichi Miura</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author><author><name sortKey="Mochizuki, Naoki" sort="Mochizuki, Naoki" uniqKey="Mochizuki N" first="Naoki" last="Mochizuki">Naoki Mochizuki</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5-7-1, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author></analytic><series><title level="j">Experimental & Molecular Medicine</title><idno type="ISSN">1226-3613</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Angiopoietin-1 (Ang1) binds to and activates Tie2 receptor tyrosine kinase. Ang1-Tie2 signal has been proposed to exhibit two opposite roles in the controlling blood vessels. One is vascular stabilization and the other is vascular angiogenesis. There has been no answer to the question as to how Tie2 induces two opposite responses to the same ligand. Our group and Dr. Alitalo's group have demonstrated that trans-associated Tie2 at cell-cell contacts and extracellular matrix (ECM)-anchored Tie2 play distinct roles in the endothelial cells. The complex formation depends on the presence or absence of cell-cell adhesion. Here, we review how Ang1-Tie2 signal regulates vascular maintenance and angiogenesis. We further point to the unanswered questions that must be clarified to extend our knowledge of vascular biology and to progress basic knowledge to the treatment of the diseases in which Ang1-Tie2-mediated signal is central.</p></div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Fukuhara, Shigetomo" sort="Fukuhara, Shigetomo" uniqKey="Fukuhara S" first="Shigetomo" last="Fukuhara">Shigetomo Fukuhara</name></noRegion><name sortKey="Miura, Koichi" sort="Miura, Koichi" uniqKey="Miura K" first="Koichi" last="Miura">Koichi Miura</name><name sortKey="Mochizuki, Naoki" sort="Mochizuki, Naoki" uniqKey="Mochizuki N" first="Naoki" last="Mochizuki">Naoki Mochizuki</name><name sortKey="Nagao, Kaori" sort="Nagao, Kaori" uniqKey="Nagao K" first="Kaori" last="Nagao">Kaori Nagao</name><name sortKey="Noda, Kazuomi" sort="Noda, Kazuomi" uniqKey="Noda K" first="Kazuomi" last="Noda">Kazuomi Noda</name><name sortKey="Sako, Keisuke" sort="Sako, Keisuke" uniqKey="Sako K" first="Keisuke" last="Sako">Keisuke Sako</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005F69 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005F69 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:2679245
|texte= Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:19293632" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |